Alfred was in a different class in the Norwegian capital, clocking 10.89 seconds for the victory in front of a 15,000 sell-out crowd at the Bislett Stadium.
Jamaican sprint legend Usain Bolt, making his first return to Oslo since his retirement in 2017, presented a grinning Alfred with a bouquet as she made a winning start to her Diamond League title defence.
"And I got to meet Usain Bolt -- yesterday for the first time ever and then two days running I got to meet him again. It is a great honour to have met him."
Ivorian veteran Marie-Josee Ta Lou-Smith finished second in 11.00 sec, with Britain's Dina Asher-Smith rounding out the podium (11.08).
“For the race itself, I just wanted to be competitive,” added Alfred. “I head to Stockholm now, so I have to rest and travel and compete again quickly, but I will go to win again.”
“As for my season, I am Olympic champion, so I am the one to beat, but I really want to add world champion to my name as well as Olympic champion.”
Alfred made history at the Olympics last summer when she won a first-ever medal for Saint Lucia.